Skip Navigation

University of Nebraska–Lincoln

AllergenOnline

Home of the farrp allergen protein database

71 References in Celiac Database Beta-2: 21 September 2017

Contact: Rick Goodman, rgoodman2@unl.edu

Celiac Tools Updated 21 September 2017

Browse Entries
By Peptides '1013'
By References '71'
By Proteins '68'
Sequence Search
Exact peptide match
Full FASTA

ID Authors Title Journal Pubmed
1Arentz-Hansen EH, McAdam SN, Molberg O, Kristiansen C, Sollid LM.Production of a panel of recombinant gliadins for the characterisation of T cell reactivity in coeliac disease.Gut. 2000;46:4651.10601054
2Shan L, Molberg , Parrot I, Hausch F, Filiz F, Gray GM, Sollid LM, Khosla C.Structural basis for gluten intolerance in celiac sprue. Science. 2002;297:2275-2279.Science. 2002;297:2275-2279.12351792
3van de Wal Y, Kooy YM, van Veelen PA, Pea SA, Mearin LM, Molberg O, Lundin KE, Sollid LM, Mutis T, Benckhuijsen WE, Drijfhout JW, Koning F.Small intestinal T cells of coeliac disease patients recognize a natural pepsin fragment of gliadin.Proc Natl Acad Sci USA. 1998;95:10050-10054.9707598
4van de Wal Y, Kooy Y, van Veelen P, Pea S, Mearin L, Papadopoulos G, Koning F.Selective deamidation by tissue tranglutaminase strongly enhances gliadin-specific T cell reactivity.J Immunol. 1998;161:15851588.9712018
5Mazzarella G, Maglio M, Paparo F, Nardone G, Stefanile R, Greco L, van de Wal Y, Kooy Y, Koning F, Auricchio S, Troncone R.An immunodominant DQ8 restricted gliadin peptide activates small intestinal immune response in in vitro cultured mucosa from HLA-DQ8 positive but not HLA-DQ8 negative coeliac patients.Gut. 2003;52:5762.12477760
6Hovhannisyan Z, Angela Weiss A, Martin A, Wiesner M, Tollefsen S, Yoshida K, Ciszewski C, Curran SA, Murray JA, David CS, Sollid LM, Koning F, Teyton L, Jabri B.The role of HLA-DQ8 b57 polymorphism on the anti-gluten T cell response in celiac disease.Nature. 2008;456:534-538.19037317
7van de Wal Y, Kooy YM, van Veelen P, Vader W, August SA, Drijfhout JW, Pea SA, Koning F.Glutenin is involved in the gluten-driven mucosal T cell response.Eur. J. Immunol. 1999;29:3133-3139.10540324
8Vader LW, Stepniak DT, Bunnik EM, Kooy YM, de Haan W, Drijfhout JW, van Veelen PA, Koning F.Characterization of cereal toxicity for celiac disease patients based on protein homology in grains.Gastroenterology. 2003;125:1105-1113.14517794
9Mitea C, Kooy-Winkelaar Y, van Veelen P, de Ru A, Drijfhout JW, Koning F, Dekking L.Fine specificity of monoclonal antibodies against celiac disease-inducing peptides in the gluteome.Am J Clin Nutr. 2008;88:1057-1066.18842794
10Maiuri L, Troncone R, Mayer M, Coletta S, Picarelli A, De Vincenzi M, Pavone V, Auricchio S.In vitro activities of A-gliadin synthetic peptides: damaging effect on the atrophic coeliac mucosa and activation of mucosal immune response in the treated coeliac mucosa,Scand. J. Gastroenterol. 1996;31:247253.8833354
11Sturgess R, Day P, Ellis HJ, Lundin KE, Gjertsen HA, Kontakou M, Ciclitira PJ.Wheat peptide challenge in coeliac disease. Lancet. 1994;343:758-761.7907731
14Arentz-Hansen H, Krner R, Molberg O, Quarsten H, Vader W, Kooy YM, Lundin KE, Koning F, Roepstorff P, Sollid LM, McAdam SN.The intestinal T cell response to gliadin in adult celiac disease is focused on a single deamidated glutamine targeted by tissue transglutaminase,J. Exp. Med. 2000;191:603612.10684852
15Caputo I, Barone MV, Lepretti M, Martucciello S, Nista I, Troncone R, Auricchio S, Sblattero D, Esposito C.Celiac anti-tissue transglutaminase antibodies interfere with the uptake of alpha gliadin peptide 31-43 but not of peptide 57-68 by epithelial cells.Biochim Biophys Acta. 2010;1802:717-27.20553859
16Koning F.The molecular basis of celiac disease.J Mol Recognit. 2003;16:333-336.14523946
17Tollefsen S, Arentz-Hansen H, Fleckenstein B, Molberg O, Rki M, Kwok WW, Jung G, Lundin KE, Sollid LM.HLA-DQ2 and -DQ8 signatures of gluten T cell epitopes in celiac disease.J Clin Invest. 2006;116:22262236.16878175
18Arentz-Hansen H, Fleckenstein B, Molberg , Scott H, Koning F, Jung G, Roepstorff P, Lundin KE, Sollid LM.The molecular basis for oat intolerance in patients with celiac disease.PLoS Med. 2004;1:e1.15526039
19Vader W, Kooy Y, Van Veelen P, De Ru A, Harris D, Benckhuijsen W, Pea S, Mearin L, Drijfhout JW, Koning F.The gluten response in children with celiac disease is directed toward multiple gliadin and glutenin peptides.Gastroenterology. 2002;122:1729-1737.12055577
20Stepniak D, Vader LW, Kooy Y, van Veelen PA, Moustakas A, Papandreou NA, Eliopoulos E, Drijfhout JW, Papadopoulos GK, Koning F.T-cell recognition of HLA-DQ2-bound gluten peptides can be influenced by an N-terminal proline at p-1.Immunogenetics. 2005;57:8-15.15714306
21Stepniak D, Wiesner M, de Ru AH, Moustakas AK, Drijfhout JW, Papadopoulos GK, van Veelen PA, Koning F.Large-scale characterization of natural ligands explains the unique gluten-binding properties of HLA-DQ2.J Immunol. 2008;180:3268-3278.18292551
22Vader LW, de Ru A, van der Wal Y, Kooy YM, Benckhuijsen W, Mearin ML, Drijfhout JW, van Veelen P, Koning F.Specificity of tissue transglutaminase explains cereal toxicity in celiac disease.J Exp Med. 2002;195:643-649.11877487
23Arentz-Hansen H, McAdam SN, Molberg , Fleckenstein B, Lundin KE, Jrgensen TJ, Jung G, Roepstorff P, Sollid LM.Celiac lesion T cells recognize epitopes that cluster in regions of gliadins rich in proline residues.Gastroenterology. 2002;123:803-809. 12198706
24Sjstrm H, Lundin KE, Molberg O, Krner R, McAdam SN, Anthonsen D, Quarsten H, Norn O, Roepstorff P, Thorsby E, Sollid LM.Identification of a gliadin T-cell epitope in coeliac disease: general importance of gliadin deamidation for intestinal T-cell recognition.Scand J Immunol. 1998;48:111-115. 9716100
25Qiao SW, Bergseng E, Molberg O, Jung G, Fleckenstein B, Sollid LM.Refining the rules of gliadin T cell epitope binding to the disease-associated DQ2 molecule in celiac disease: importance of proline spacing and glutamine deamidation.J Immunol. 2005;175:254-261. 15972656
27Koning F, Gilissen L, Wijmenga C.Gluten: a two-edged sword. Immunopathogenesis of celiac disease.Springer Semin Immunopathol. 2005;27:217-232.16091925
28Anderson RP, Degano P, Godkin AJ, Jewell DP, Hill AV.In vivo antigen challenge in celiac disease identifies a single transglutaminase-modified peptide as the dominant A-gliadin T-cell epitope.Nat Med 2000;6:337342.10700238
29de Ritis G, Auricchio S, Jones HW, Lew EJ-L, Bernardin JE, Kasarda DD.In-vitro (organ culture) studies of the toxicity of specific A-gliadin peptides in celiac disease.Gastroenterology. 1988;94:41-49.3335296
30Gianfrani C, Troncone R, Mugione P, Cosentini E, De Pascale M, Faruolo C, Senger S, Terrazzano G, Southwood S, Auricchio S, Sette A.Celiac disease association with CD8+ T cell responses: identification of a novel gliadin-derived HLA-A2-restricted epitope.J Immunol. 2003. 170;5:27192726.12594302
34Lundin KE, Scott H, Hansen T, Paulsen G, Halstensen TS, Fausa O, Thorsby E, Sollid LM.Gliadin-specific, HLA-DQ (a1*0501,1*0201) restricted T cells isolated from the small intestinal mucosa of celiac disease patients.J Exp Med. 1993;178:187196.8315377
35Mantzaris G, Jewell DP.In vivo toxicity of a synthetic dodecapeptide from A gliadin in patients with coeliac disease.Scand J Gastroenterol. 1991;26:392398.1827928
37Martucci S, Fraser JS, Biagi F, Corazza GR, Ciclitira PJ, Ellis HJ.Characterizing one of the DQ2 candidate epitopes in coeliac disease: A-gliadin 5170 toxicity assessed using an organ culture system.Eur J Gastroenterol Hepatol. 2003;15:12931298.14624152
39Gjertsen HA, Lundin KE, Sollid LM, Eriksen JA, Thorsby E.T cells recognize a peptide derived from alpha-gliadin presented by the celiac disease-associated HLA-DQ (alpha 1*0501, beta 1*0201) heterodimer.Hum Immunol. 1994;39:243-252.7520895
40Wieser H, Belitz HD, Ashkenazi A.Amino-acid sequence of the coeliac active gliadin peptide B 3142.Z Lebensm Unters Forsch. 1984;179:371376.6524078
41Wieser H, Belitz HD, Idar D, Ashkenazi A.Coeliac activity of the gliadin peptides CT-1 and CT-2.Z. Lebensm. Unters. Forsch. 1986;182:115117.3705771
42Devery JM, Bender V, Penttila I, Skerritt JH.Identification of reactive synthetic gliadin peptides specific for coeliac disease.Int Arch Allergy Appl Immunol 1991;95:356362.1720424
43Quarsten H, McAdam SN, Jensen T, Arentz-Hansen H, Molberg O, Lundin KE, Sollid LM.Staining of celiac disease-relevant T cells by peptide-DQ2 multimers.J Immunol. 2000;167:48614868.11673490
44Vader W, Stepniak D, Kooy Y, Mearin L, Thompson A, van Rood JJ, Spaenij L, Koning F.The HLA-DQ2 gene dose effect in celiac disease is directly related to the magnitude and breadth of gluten-specific T cell responses.Proc. Natl. Acad. Sci. USA. 2003;100:1239012395.14530392
45Hausch F, Shan L, Santiago NA, Gray GM, Khosla C.Intestinal digestive resistance of immunodominant gliadin peptides.Am J Physiol Gastrointest Liver Physiol. 2002;283:G996-G1003.12223360
46Black KE, Murray JA, David CS.HLA-DQ determines the response to exogenous wheat proteins: a model of gluten sensitivity in transgenic knockout mice.J Immunol. 2002;169: 55955600. 12421937
47Molberg , Uhlen AK, Jensen T, Solheim Flaete N, Fleckenstein B, Arentz-Hansen H, Raki M, Lundin KEA, Sollid LM.Mapping of gluten T cell epitopes in the bread wheat ancestors: implications for celiac disease.Gastroenterology 2005;128:393-401.15685550
48Shan L, Qiao SW, Arentz-Hansen H, Molberg , Gray GM, Sollid LM, Khosla C.Identification and analysis of multivalent proteolytically resistant peptides from gluten: implications for celiac sprue.J Proteome Res. 2005;4:1732-1741.16212427
49Shidrawi RG, Day P, Przemioslo R, Ellis HJ, Nelufer JM, Ciclitira PJ.Invitro toxicity of gluten peptides in celiac disease assessed by organ culture.Scand J Gastroenterol. 1995; 30:758-763.7481543
50Biagi F, Ellis HJ, Parnell ND, Shidrawi RG, Thomas PD, O'Reilly N, Corazza GR, Ciclitira PJ.A non-toxic analogue of a celiac-activating gliadin peptide: a basis for immunomodulation?Aliment Pharmacol Ther. 1999;13:945-950.10383530
51Ellis HJ, Pollock EL, Engel W, Fraser JS, Rosen-Bronson S, Wieser H, Ciclitira PJ.Investigation of the putative immunodominant T cell epitopes in coeliac disease.Gut. 2003;52:212-217.12524402
52Moustakas AK, van de Wal Y, Routsias J, Kooy YM, van Veelen P, Drijfhout JW, Koning F, Papadopoulos GK.Structure of celiac disease-associated HLA-DQ8 and non-associated HLA-DQ8 alleles in complex with two disease-specific epitopes.Int Immunol. 2000;12:1157-1166.10917890
54Henderson KN, Tye-Din JA, Reid HH, Chen Z, Borg NA, Beissbarth T, Tatham A, Mannering SI, Purcell AW, Dudek NL, van Heel DA, McCluskey J, Rossjohn J, Anderson RP.A structural and immunological basis for the role of human leukocyte antigen DQ8 in celiac disease.Immunity. 2007;27:23-34.17629515
55Molberg , Mcadam SN, Krner R, Quarsten H, Kristiansen C, Madsen L, Fugger L, Scott H, Norn O, Roepstorff P, Lundin KE, Sjstrm H, Sollid LM.Tissue transglutaminase selectively modifies gliadin peptides that are recognized by gut derived T cells in celiac disease.Nat. Med. 1998;4:713717.9623982
56Quarsten H, Molberg , Fugger L, McAdam SN, Sollid LM.HLA binding and T cell recognition of a tissue transglutaminase modified gliadin epitope.Eur. J. Immunol. 1999;29:25062514.10458765
57Camarca A, Anderson RP, Mamone G, Fierro O, Facchiano A, Costantini S, Zanzi D, Sidney J, Auricchio S, Sette A, Troncone R, Gianfrani C.Intestinal T cell responses to gluten peptides are largely heterogeneous: implications for a peptide-based therapy in celiac disease.J Immunol. 2009;182:4158-4166.19299713
59Mitea C, Salentijn EM, van Veelen P, Goryunova SV, van der Meer IM, van den Broeck HC, Mujico JR, Monserrat V, Gilissen LJ, Drijfhout JW, Dekking L, Koning F, Smulders MJ.A universal approach to eliminate antigenic properties of alpha-gliadin peptides in celiac disease.PLoS One. 2010;5:e15637.21179575
60Lammers KM, Khandelwal S, Chaudhry F, Kryszak D, Puppa EL, Casolaro V, Fasano A.Identification of a novel immunomodulatory gliadin peptide that causes interleukin-8 release in a chemokine receptor CXCR3-dependent manner only in patients with coeliac disease.Immunology. 2011 Mar;132(3):432-4021091908
61Drum S, Arntzen M, Qiao SW, Holm A, Koehler CJ, Thiede B, Sollid LM, Fleckenstein B.The preferred substrates for transglutaminase 2 in a complex wheat gluten digest are Peptide fragments harboring celiac disease T-cell epitopes.PLoS One. 2010;5:e14056.21124911
62Tye-Din JA, Stewart JA, Dromey JA, Beissbarth T, van Heel DA, Tatham A, Henderson K, Mannering SI, Gianfrani C, Jewell DP, Hill AV, McCluskey J, Rossjohn J, Anderson RP.Comprehensive, quantitative mapping of T cell epitopes in gluten in celiac disease.Sci Transl Med. 2010;2:41ra5120650871
63Fraser JS, Enoel W, Ellis HJ, Moodie SJ, Pollock EL, Wieser H, Ciclitira PJ.Coeliac disease In-vivo toxicity of the putative immunodominant epitope.Gut. 2003;52:1698-1702. 14633945
64Mazzarella G, Stefanile R, Camarca A, Giliberti P, Cosentini E, Marano C, Iaquinto G, Giardullo N, Auricchio S, Sette A, Troncone R, Gianfrani C.Gliadin activates HLA class I-restricted CD8+ T cells in celiac disease intestinal mucosa and induces the enterocyte apoptosis.Gastroenterology. 2008 Apr;134(4):1017-27. doi: 10.1053/j.gastro.2008.01.008. Epub 2008 Jan 11.18395083
66Johansen BH, Gjertsen HA, Vartdal F, Buus S, Thorsby E, Lundin KE, Sollid LM.Binding of peptides from the N-terminal region of alpha-gliadin to the celiac disease-associated HLA-DQ2 molecule assessed in biochemical and T cell assays.Clin Immunol Immunopathol. 1996 Jun;79(3):288-938635288
68Qiao SW, Bergseng E, Molberg , Xia J, Fleckenstein B, Khosla C, Sollid LMAntigen presentation to celiac lesion-derived T cells of a 33-mer gliadin peptide naturally formed by gastrointestinal digestionJ Immunol. 2004 Aug 1;173(3):1757-6215265905
69Lammers KM, Lu R, Brownley J, Lu B, Gerard C, Thomas K, Rallabhandi P, Shea-Donohue T, Tamiz A, Alkan S, Netzel-Arnett S, Antalis T, Vogel SN, Fasano AGliadin induces an increase in intestinal permeability and zonulin release by binding to the chemokine receptor CXCR3Gastroenterology. 2008 Jul;135(1):194-204.e318485912
72Barone MV, Gimigliano A, Castoria G, Paolella G, Maurano F, Paparo F, Maglio M, Mineo A, Miele E, Nanayakkara M, Troncone R, Auricchio SGrowth factor-like activity of gliadin, an alimentary protein: implications for coeliac diseasGut. 2007 Apr;56(4):480-8. Epub 2006 Aug 416891357
74Salentijn EM, Mitea DC, Goryunova SV, Van der Meer II, Padioleau I, Gilissen LJ, Koning F, Smulders MJCeliac disease T-cell epitopes from gamma-gliadins: immunoreactivity depends on the genome of origin, transcript frequency, and flanking protein variationBMC Genomics. 2012 Jun 22;13(1):27722726570
76Kooy-Winkelaar Y, van Lummel M, Moustakas AK, Schweizer J, Mearin ML, Mulder CJ, Roep BO, Drijfhout JW, Papadopoulos GK, van Bergen J, Koning FGluten-specific T cells cross-react between HLA-DQ8 and the HLA-DQ2a/DQ8 transdimerJ Immunol. 2011 Nov 15;187(10):5123-922013116
77Bodd M, Kim CY, Lundin KE, Sollid LMT-cell response to gluten in patients with HLA-DQ2.2 reveals requirement of peptide-MHC stability in celiac diseaseGastroenterology. 2012 Mar;142(3):552-6122108197
78Sollid LM, Qiao SW, Anderson RP, Gianfrani C, Koning FNomenclature and listing of celiac disease relevant gluten T-cell epitopes restricted by HLA-DQ moleculeImmunogenetics. 2012 Jun;64(6):455-6022322673
79Auricchio S, De Ritis G, De Vincenzi M, Occorsio P, Silano VEffects of gliadin-derived peptides from bread and durum wheats on small intestine cultures of rat fetus and Coeliac childrenPediatr Res. 1982; 16:1004-10107155669
81Qiao SW, Iversen R, Rakl M, Sollid LMThe adaptive immune response in celiac diseaseSemin. Immunopathol. 2012; 34:523-54022535446
82Mamone G, Ferranti P, Melck D, Tafuro F, Longobardo L, Chianese L, Addeo FSusceptibility to transglutaminase of gliadin peptides predicted by a mass spectrometry-based assayFEBS Lett. 2004; 562:177-18215044021
83Bodd M, Tollefsen S, Bergseng E, Lundin KEA, Sollid LMEvidence that HLA-DQ9 confers risk to celiac disease by presence of DQ9-restricted gluten specific T cells Human Immunology. 2012. 73:376-38122342873
84Kim CY, Quarsten H, Bergseng E, Khosla C, Sollid LMStructural basis for HLA-DQ2-mediated presentation of gluten epitopes in celiac diseasePNAS 2004. 101(12):4175-417915020763
86Hardy MY, Girardin A, Pizzey C, Cameron DJ, Watson KA, Picascia S, Auricchio R, Greco L, Gianfrani C, La Gruta NL, Anderson RP, Tye-Dyn JAConsistency in polyclonal T-cell responses to gluten between children and adults with celiac diseaseGastroenterology. 2015. 149:1541-155226226573
87Real A, Comino I, de Lorenzo L, Merchan F, Gil-Humanes J, Gimenez MJ, Lopez-Casado MA, Torres MI, Cebolla A, Sousa C, Barro F, Pison FMolecular and immunological characterization of gluten proteins isolated from oat cultivars that differ in toxicity for celiac diseasePLOS One. 2012. 7(12):e4836523284616
88Hardy MY, Tye-Din JA, Stewart JA, Schmitz F, Dudek NL, Hanchapola I, Purcell AW, Anderson RPIngestion of oats and barley in patients with celiac disease mobilizes cross-reactive T cells activated by avenin peptides and immuno-dominant hordein peptidesJ Autoimmunity. 2015. 56:56-6525457306
91Rocher A, Calero M, Soriano F, Mendoza EIdentification of major rye secalins as coeliac immunoreactive proteinsBiochim Biophys Acta 1996. 1295(1):13-228679669
90EFSA GMO Panel, Naegeli H, Birch AN, Casacuberta J, De Schrijver A, Guidance on allergenicity assessment of genetically modified plants.EFSA Journal. 2017. 15(5):Annex A, 18-28.