Latest News:
| New Version | |
|---|---|
| Version # | 10 |
| Peer Reviewed Sequences | 1471 |
| Released On | Jan 2010 |
| New Features | |
| Database History page | |
| Improved DB Browsing | |
| Exact Shortmer added to Sequence Search | |
Welcome To AllergenOnline
AllergenOnline provides access to a peer reviewed allergen list and sequence searchable database intended for identifying proteins that may present a potential risk of allergenic cross-reactivity. This website was designed to help in assessing the safety of proteins that may be introduced into foods through genetic engineering or food processing methods.
Features and Tools Available.
Sequence search routines for food safety
- We continue provide search routines to allow you to compare a protein sequence with the sequences in the AllergenOnline database (current version 10). This is intended primarily for evaluating new proteins in Genetically Modified crops or in Novel Foods.
- Search for full-length alignments by FASTA: The most predictive search is the overall FASTA alignment (see FASTA Help Page), with identity matches greater than 50% indicating possible cross-reactivity.
- Search for 80 amino acid alignments by FASTA: A precautionary search is a sliding window of 80 amino acid searches, looking for identities greater than 35% (according to CODEX Alimentarius guidelines, 2003).
- Search for 8 amino acid exact match: We have just added an 8 amino acid exact identity match search as a precautionary search for regulatory studies in countries that require that comparison. Our scientific opinion is that there is no evidence that an 8 amino acid match will identify a protein that is likely to be cross-reactive and could be missed by the conservative 80 amino acid match (35%). In our experience, isolated matches of 8 occur by chance alone, but since regulators in some countries insist upon viewing these results, we now provide this tool so that this search can be performed efficiently with our database.
Browse the database
- Allergen Groups: Multiple isoforms or close homologues of proteins contained in the database were clustered into related groups based on taxonomy and sequence identity. These are presented in the final column of the allergen lists viewed under the "Browse" function.
Group names consist of the genus name, followed in some cases by IUIS, or IUIS-like designations (e.g. Arachis Ara h 1), or protein type names (e.g. Crocus profilin). - References: The group name links to "Group References" describing the evidence of allergenicity for the group and a list of "Group Sequences" included in this version of the database.
Who We Are
Allergen Online Team
This database was developed and is maintained by the Food Allergy Research and Resource Program (FARRP) in the Department of Food Science and Technology at the University of Nebraska in Lincoln.
Peer Reviewers
A panel of scientists and clinicians are actively involved in reviewing data for inclusion of proteins in the database by comparing peer reviewed publications supporting the classification of the proteins as allergens or putative allergens following predetermined guidelines.
- Motohiro Ebisawa, M.D.,
National Sagamihara Hospital, Sagamihara, Japan - Fatima Ferreira, Ph.D.,
University of Salzburg, Salzburg, Austria - Richard E. Goodman, Ph.D.,
University of Nebraska, Lincoln, NE, USA - Hugh A. Sampson, M.D.,
Mount Sinai Medical Center, New York, NY, USA
- Steve L. Taylor, Ph.D.,
University of Nebraska, Lincoln, NE, USA - Ronald van Ree, Ph.D.,
Academic Medical Center, Amsterdam, The Netherlands - Stefan Vieths, Ph.D.,
Paul-Ehrlich-Institut, Langen, Germany
Financial Support
Financial support for this database is provided by grants from corporate sponsors and FARRP (the University of Nebraska-Lincoln).
Sponsors include:
- BASF Plant Science, LLC
- Bayer CropScience, S.A.
- Dow AgroSciences, LLC
- Monsanto Company, LLC
- Pioneer Hi-Bred International, Inc., a DuPont Company
- Syngenta Biotechnology, Inc.
Liability statement
The content of the AllergenOnline.org database is the sole responsibility of researchers at the University of Nebraska-Lincoln, with the advice and collaboration of additional independent academic and medical consultants. This work is co-sponsored by the aforementioned corporate sponsors and the Food Allergy Research and Resource Program at the University of Nebraska-Lincoln. Corporate sponsors have the right to provide scientific input. However, all decisions regarding content are the responsibility of the FARRP panel. The sponsors and the University of Nebraska, make no representations or warranties of any kind, express or implied, concerning the content of the database, including, without limitation, warranties of merchantability, fitness for a particular purpose, non-infringement, validity of any intellectual property rights or claims, whether issued or pending, and the absence of latent or other defects, whether or not discoverable.
Bioinformatic Allergen Assessment Reports
| Golden Rice 2 |
| Report: FARRP Bioinformatic Analysis of Proteins in Golden Rice 2 to Assess Potential Allergenic Cross-Reactivity Download: Golden Rice 2 Bioinformatics FARRP 2006.pdf
Project Homepage: www.goldenrice.org |
About: Golden Rice is a biofortified crop created to address
the problem of vitamin A deficiency in developing countries. This was done through
genetic modification of the rice plant to produce and
accumulate provitamin A in the grain, a trait not found in nature.
For further information on Golden Rice and the orginization that developed it, please refer to the project homepage.
