Allergen Database

Download as PDF: AllergenOnlineV19.pdf

Species Common IUIS Allergen Type Group Allergenicity Length Accession GI# 1st Version
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  • Allergen Source: Sequences of allergens are compiled in a table under "species", shown in the left-hand column (scientific name: genus and species). The common name of the source is listed.
  • Each sequence is listed separately: And there can be multiple isoforms or partial sequences for a single allergen (e.g. Actinidia deliciosa Act d 1)
  • WHO/IUIS Allergen Nomenclature: (World Health Organization/International Union of Immunological Societies) designation or name is shown if known abbreviated as IUIS.
  • Type of allergen is shown: (e.g. Aero plant, food animal, venom or salivary)
  • Allergen Groups: Group names include the genus and protein type or IUIS designation.  Multiple isoforms or close homologues of proteins contained in the database were clustered based on taxonomy of the source organism and sequence identity of the proteins. Evidence of allergenicity is assembled and evaluated for the collective sequences within one group, for review by the AllergenOnline.org expert panel and for presentation of references related to the sequences.  The allergen “group” is linked to more information including the published references describing the information used to classify the protein as an allergen, as well as the individual sequences clustered into the group.  The Accession# and GI# in the table of allergens are linked to the NCBI entries to show the complete NCBI entry, although GI#s are no-longer shown in NCBI. Publication references are listed in the Group or gid list.  References may apply to a single sequence, or multiple sequences in the group. They provide evidence of the allergenicity of the source.
  • Allerginicity: Peer-reviewed publications describe IgE binding only (western blot, ELISA) without biological activity; or IgE binding plus biological activity test as measured by basophil activation or IgE plus Skin Prick test. NOTE Addition of Allergenicity column with classification based on Group references was added on 10 May 2018.
  • References: The group name links to "Group References" describing the evidence of allergenicity for the group and a list of "Group Sequences" included in this version of the database.
  • Length: The number of amino acids is shown for each allergen entry
  • Accession# and GI#: The NCBI record number is shown for the single entry and it is linked directly to NCBI for viewing.
  • Version:The database version that the specific allergen was entered is included (e.g. 7, 9, 11, 18). See Version History.